Modulation of microglial phenotypes by dexmedetomidine through TREM2 reduces neuroinflammation in heatstroke
نویسندگان
چکیده
منابع مشابه
Dexmedetomidine reduces lipopolysaccharide induced neuroinflammation, sickness behavior, and anhedonia
BACKGROUND Peripheral innate immune response may induce sickness behavior through activating microglia, excessive cytokines production, and neuroinflammation. Dexmedetomidine (Dex) has anti-inflammatory effect. We investigated the effects of Dex on lipopolysaccharide (LPS)-induced neuroinflammation and sickness behavior in mice. MATERIALS AND METHODS BALB/c mice were intraperitoneally (i.p.) ...
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1 LSU Neuroscience Center, Louisiana State University Health Sciences Center (LSUHSC), New Orleans, LA, USA 2 Department of Health Information Management, Louisiana State University, Ruston, LA, USA 3 Department of Ophthalmology, Health Sciences Center, Louisiana State University, New Orleans, LA, USA 4 Department of Neurology, Health Sciences Center, Louisiana State University, New Orleans, LA...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2021
ISSN: 2045-2322
DOI: 10.1038/s41598-021-92906-5